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A severe complication of allogeneic hematopoietic stem cell transplantation (HSCT) is graft failure (GF). Among others, donor‐specific anti‐HLA antibodies (DSA) are associated with graft rejection after allogeneic or haploidentical transplantation in adults. Knowledge of DSA and pediatric recipients is limited. Hence, we aimed to generate more information about the presence of DSA (pre‐ and post‐HSCT)...
Until recently the number of alleles of the nonclassical HLA class I gene HLA‐E documented in the IPD‐IMGT/HLA Database was small and as a result, the gene was often not considered to be notably polymorphic. Here, we describe our work in identifying and submitting 86 novel HLA‐E alleles after full‐gene single‐molecule real‐time (SMRT) DNA sequencing of 6227 DNA samples. These samples were comprised...
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